IgG deficiency Case Study Example | Topics and Well Written Essays - 500 words

IgG deficiency - Case Study Example IgG1 and IgG3 subclasses have antibodies that act on protein antigens and therefore inhibit roles of the antigens. Antibodies of IgG2 and IgG4, however, acts on antigens of â€Å"carbohydrates and polysaccharide† to impair functions of the antigens (Porth, 2011, p. 361). Defficiency of IgG2 leads to â€Å"sinusitis, otitis media, and pneumonia† that arise from bacteria that are embedded in polysaccharides. Examples of such bacteria are â€Å"S. pneumonia, H. influenza type b, and N. meningitidis† (p. 361). McMillan, Feigin, DeAngelis, & Jones (2006), however, argue that IgG4, unlike the other subclasses, do not have a binding effect that leads to cytotoxicity. No cause of IgG has been identified but genetics is suspected o play a significant role. Parents transfer genes to their children and the genes are responsible for protein development in the body of the offspring. Transferred defective gene is likely to imply defective development of elements of cells that relate to that gene and this suggest high susceptibility of IgG deficiency for people whose parents have the complication (Johns Hopkins University, n.d.). There is no treatment for IgG deficiency but management approaches exist. the approaches target specific infection that arise from the deficiency and not the deficiency. Some of the management approaches, according to The Centers for Disease Control and Prevention (2015), are vaccine against pneumonia and other live vaccines. â€Å"OPV2, BCG, yellow fever,† vaccines are however contraindicated. The recommended vaccines reduce susceptibility to the infections and therefore undermine pathophyliology of IgG deficiency (n.p. ). While these aim at preventing occurrence of associated complication, treatment of the complication is an alternative measure to managing IgG deficiency. Infections such as allergies may reoccur and require constant antibiotic medication. In extreme cases, however, direct